In Vivo Analysis, Biocompatibility and Immune Response of Jellagen 3D Scaffolds

Jellagen 3D Scaffolds were shown to have excellent biocompatibility and can successfully support the process of (bone) tissue regeneration.

The recent publication in the International Journal of molecular Sciences titled “In Vivo Analysis of the Biocompatibility and Immune Response of Jellyfish Collagen Scaffolds and its Suitability for Bone Regeneration” concluded that:

  • Jellyfish collagen, can be defined as “collagen type 0” due to its homogeneity to the mammalian types I, II, III, V, and IX.
  • The degradation process ended in a vessel-rich connective tissue that is supposed to be an optimal basis for (bone) tissue regeneration.
  • Results showed an overall weaker immune response to the jellyfish collagen than to porcine pericardium matrices, as significantly lower numbers of macrophages were observed within the subcutaneous implant beds of the jellyfish collagen scaffolds compared to the respective numbers in the implant beds of the porcine pericardium matrices.
  • The study revealed a long-term anti-inflammatory response to the jellyfish collagen scaffolds in the cavarial implantation beds.


Read the paper

To find more information on the 3D Scaffolds used in this project, visit the product page.

About the International Journal of Molecular Sciences 

International Journal of Molecular Sciences (ISSN 1422-0067; CODEN: IJMCFK; ISSN 1661-6596 for printed edition) is an international peer-reviewed open access journal providing an advanced forum for biochemistry, molecular and cell biology, molecular biophysics, molecular medicine, and all aspects of molecular research in chemistry, and is published semi-monthly online by MDPI